This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

Dopamine action on hippocampal representations of space and memory

This month Colin McNamara and colleagues report compelling evidence of how rewarding or novel experiences strengthen newly-encoded spatial memories. The hippocampus provides the brain with representations of space (J. O'Keefe and J. Dostrovsky, 1971) but newly-formed hippocampal representations may degrade with time unless stabilized by additional processes.

In this study, the Unit members show that hippocampal sleep reactivation during sharp wave/ripple events (thought important for memory consolidation) can be primed through optogenetic activation of dopaminergic afferents within the hippocampus. These dopaminergic fibres project from the brain’s reward centre in the midbrain, the VTA (ventral tegmental area). Neurons within the VTA are active during exploration of novel environments and learning of new goal locations. They further demonstrated that this optogenetic activation of the dopaminergic fibres within the hippocampus increased memory persistence measured through both behavioural performance and the sustained stability of hippocampal representations of space. These results establish a link through which the brain’s reward system can produce increased memory persistence.

See also the Nature Neuroscience the News and Views piece about this article at