This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

News- Neurogliaform cells and other interneurons of stratum lacunosum-moleculare gate entorhinal­hippocampal dialogue

Published by Marco Capogna in the Journal of Physiology 589.8: 1875-1883, 2011 (PDF). 

Abstract: The stratum lacunosum moleculare of the hippocampus is an area of integration that receivesinputs from extrinsic excitatory fibres including those from the entorhinal cortex, and is underthe control of several neuromodulators. A critical aspect is the presence in this hippocampal layerof specific interneurons that are likely to influence the strength and the temporal structure ofentorhinal­CA1 hippocampal dynamics. I review here recent data on the physiological role ofthese interneurons. Special focus is devoted to one interneuron type, the so-called neurogliaformcell, because recent studies have defined its unusual mode of cell-to-cell communication. Neurogliaformcells mediate feedforward inhibition of CA1 pyramidal cells, form a network of cellsconnected via chemical and electrical synapses, and evoke slow inhibitory synaptic currentsmediated by GABAA and GABAB receptors. The modulation of entorhinal input by neurogliaformcells and their contribution to network theta rhythm are also discussed. I hope thatnovel information on neurogliaform cells will contribute to the ever-growing appreciation ofGABAergic cell type diversity, and will inspire neuroscientists interested not only in synapticphysiology but also in the brain's spatial representation system.