Functional properties of fast spiking GABAergic interneurons in thehippocampal network.Prof. Peter Jonas, Institute of Science and Technology (IST), Vienna, Austria.
Prof. Jonas' Lecture focused on two aspects constantly present in Prof. Smith's scientific thinking and production: exocytosis and GABAergic cells. In his Lecture, the speaker illustrated the mechanisms underlying release of the neurotransmitter GABA by parvalbumin-expressing interneurons of the rat hippocampus. At these synapses, the "nanodomain" coupling between calcium channels and calcium sensors promotes fast and efficient transmitter release. Furthermore, an unexpected small number of calcium channels trigger transmitter release. Finally, GABA released by these interneurons is rapid and highly synchronised. Combined these factors ensure that parvalbumin-expressing GABAergic cells operate with high speed and temporal precision.
The Lecture was set up to celebrate the vision of the previous Chair ofPharmacology Prof. A. David Smith, Honorary Associate Director and founderof the Unit, and the successful conclusion of the latest quinquennialscientific review of the Unit.
To commemorate the Lecture, Prof. Jonas received a laser engraved cherrywood plaque, designed by Unit Artist Ben Micklem and illustrating aspectsof anatomical neuropharmacology at Oxford from molecules to the brain.
Habits, Rituals, and the Evaluative Brain
The 5th David Smith Lecture in Anatomical Neuropharmacology was given on the 21st September, by Prof. Ann Graybiel, McGovern Institute, MIT, Cambridge, USA.
The lecture was set up to celebrate the vision of the previous Chair of Pharmacology Prof. A. David Smith, Honorary Associate Director and founder of the Unit, and the successful conclusion of the latest quinquennial scientific review of the Unit.
Glutamate receptors: their localization, function, and roles in physiological learning processes
The 4th David Smith Lecture in Anatomical Neuropharmacology was given on the 4th May, by Prof. Ryuichi Shigemoto, Head of Division of Cerebral Structure, National Institute for Physiological Sciences, Okazaki, Japan, and Professor, National Institute for Physiological Sciences, The Graduate University for Advanced Studies, School of Life Science.
Cell-type specific regulation of interneuronal microcircuits in the cortex
Professor Ivan Soltesz, Department of Anatomy and Neurobiology, University of California Irvine. http://www.anatomy.uci.edu/soltesz.html delivered the 7th David Smith Lecture on the 6th March 2012, followed by dinner at Brasenose College.
Professor Jean-Marc Fritschy delivered the 11th David Smith Lecture in Anatomical Neuropharmacology.
"Plasticity of GABAergic synapses: mechanisms and implications"
The 11th David Smith Lecture in Anatomical Neuropharmacology was given on 3 March 2015 by Professor Jean-Marc Fritschy of the Institute of Pharmacology and Toxicology at the University of Zurich http://www.pharma.uzh.ch/neuromorpho
The Lecture was hosted by Professor Peter Somogyi.
Neuropeptide signalling in health and disease.
Professor Tomas Hökfelt, Department of Neuroscience, Karolinska Institutet, Stockholm, (http://ki.se/ki/jsp/polopoly.jsp?d=25981&a=55039&l=en) delivered the 8th David Smith Lecture on the 21st May 2013, followed by dinner at Lady Margaret Hall.