Limbic encephalitis (LE) is a CNS disease characterized by subacuteonset of memory loss and epileptic seizures. The paper shows that LEantibodies enhance the excitability of hippocampal CA3 pyramidal cellsproviding a cellular mechanism for the disease phenotype. This resulthas been obtained through a collaborative effort between group of MarcoCapogna, at our MRC Unit and the group of Angela Vincent at theWeatherall Institute of Molecular Medicine of the John Radcliffe Hospital.
Lalic, T., Pettingill, P., Vincent, A. & Capogna, M. (2010) Human limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission. Epilepsia, DOI: 10.1111/j.1528-1167.2010.02756.x Full text (PDF).
Tatjana Lalic successfully defended her D.Phil. thesis, 'Synaptic transmission of hippocampal mossy fibres in health and disease', on the 4th of December 2009. Tatjana was supervised by Dr. Marco Capogna. Her internal examiner was Dr. Colin Akerman (on the right), and her external was Dr. Urs Gerber from the University of Zurich, Switzerland (on the left).