Anatomical Neuropharmacology Unit

This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

News- Tatjana Lalic and colleague's paper published on hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission enhanced by human limbic encephalitis serum.

10 Nov 2010

Limbic encephalitis (LE) is a CNS disease characterized by subacuteonset of memory loss and epileptic seizures. The paper shows that LEantibodies enhance the excitability of  hippocampal CA3 pyramidal cellsproviding a cellular mechanism for the disease phenotype. This resulthas been obtained through a collaborative effort between group of MarcoCapogna, at our MRC Unit and the group of Angela Vincent at theWeatherall Institute of Molecular Medicine of the John Radcliffe Hospital.

Lalic, T., Pettingill, P., Vincent, A. & Capogna, M. (2010) Human limbic encephalitis serum enhances hippocampal mossy fiber-CA3 pyramidal cell synaptic transmission. Epilepsia, DOI: 10.1111/j.1528-1167.2010.02756.x Full text (PDF).