This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

Which molecules regulate synaptic brain asymmetries?

A perspective paper has been published by Marco Capogna in the last issue of the Journal of Physiology (591.19). This article comments a paper published by Lujan, Shigemoto (ex Unit members), Ito and collaborators published in the same issue of the Journal of Physiology ( The paper by Ito & coll. is the first to dissect out the cellular process that generates molecular asymmetries in the brain. Specifically, it identifies the major histocompatibility complex class I as key molecules involved in regulation of the asymmetry of NMDA receptors at hippocampal synapses.