Anatomical Neuropharmacology Unit

This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

Adaptation and bursting in neocortical neurones may be controlled by a single fast potassium conductance.

Q J Exp Physiol 1989;74(2):223-6.

Adaptation and bursting in neocortical neurones may be controlled by a single fast potassium conductance.

Berman NJ, Bush PC, Douglas RJ
Abstract:
We have used computer simulation of a model neurone and in vitro intracellular recording to demonstrate that the adaptation of repetitive discharge in neocortical neurones can be explained by a fast potassium current whose inactivation is retarded by intracellular calcium. The maximum amplitude of this current determines whether the neurone will discharge in regular or burst mode.
Research and Techniques: 
Adaptation, Physiological
Animals
cerebral cortex
Computer Simulation
Models, Neurological
Neurons
Potassium
Rats