Anatomical Neuropharmacology Unit

This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction.

News Physiol. Sci. 2001;16():214-7.

ATP-sensitive potassium channels in dopaminergic neurons: transducers of mitochondrial dysfunction.

Liss B, Roeper J
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Abstract:
ATP-sensitive potassium (K(ATP)) channels directly couple the metabolic state of a cell to its electrical activity. Dopaminergic midbrain neurons express alternative types of K(ATP) channels mediating their differential response to mitochondrial complex I inhibition. Because reduced complex I activity is present in Parkinson's Disease, differential K(ATP) channel expression suggests a novel candidate mechanism for selective dopaminergic degeneration.
Research and Techniques: 
Adenosine Triphosphate
Animals
Dopamine
Mitochondria
Mitochondrial Diseases
Neurons
Parkinson Disease
Potassium Channels