Anatomical Neuropharmacology Unit

This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

Brain Res. 2008;1221():93-7. 10.1016/j.brainres.2008.05.019

Increased electrical and metabolic activity in the dorsal raphe nucleus of Parkinsonian rats.

Kaya AH, Vlamings R, Tan S, Lim L W, Magill PJ, Steinbusch HWM, Visser-Vandewalle V, Sharp T, Temel Y

Full text PDF download:

kaya2008brainres.pdf

Abstract:

Serotonin (5-HT) containing neurons in the dorsal raphe nucleus (DRN) may play important roles in Parkinson's disease (PD). This study investigated neural and metabolic activity of the DRN in animal PD models based on dopamine depletion. The data show both increased firing rate of DRN 5-HT neurons and increased cytochrome oxidase activity in dopamine-depleted rats, as compared to controls. These data support the hypothesis that the DRN 5-HT system is hyperactive in the dopamine-depleted brain.

Research and Techniques:

Electron Transport Complex IV

Parkinsonian Disorders