This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.

Nat. Neurosci. 2009;12(1):21-3. 10.1038/nn.2230

Interneurons hyperpolarize pyramidal cells along their entire somatodendritic axis.

Glickfeld LL, Roberts DJ, Somogyi P, Scanziani M
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Abstract:
Although GABAergic interneurons are the main source of synaptic inhibition in the cortex, activation of GABA(A) receptors has been shown to depolarize specific neuronal compartments, resulting in excitation. By using a noninvasive approach to monitor the effect of individual interneurons on the pyramidal cell population, we found that rat hippocampal interneurons hyperpolarized pyramidal cells irrespective of the location of their synapses along the somato-dendritic axis.