This is an historical archive of the activities of the MRC Anatomical Neuropharmacology Unit (MRC ANU) that operated at the University of Oxford from 1985 until March 2015. The MRC ANU established a reputation for world-leading research on the brain, for training new generations of scientists, and for engaging the general public in neuroscience. The successes of the MRC ANU are now built upon at the MRC Brain Network Dynamics Unit at the University of Oxford.

Presence of a soluble form of acetylcholinesterase in human ocular fluids.

Br J Ophthalmol 1991;75(5):276-9.

Presence of a soluble form of acetylcholinesterase in human ocular fluids.

Appleyard ME, McDonald B, Benjamin L
Abstract:
Samples of ocular fluid obtained from normal persons at necropsy and during eye surgery have been assayed for the presence of acetylcholinesterase. Measurable levels could be detected in all samples examined, but levels of acetylcholinesterase in vitreous humour were consistently higher than those in aqueous humour, indicating a possible retinal origin. Polyacrylamide gel electrophoresis revealed that the enzyme of ocular fluid had the same mobility as that of acetylcholinesterase from cerebrospinal fluid. It is probable that acetylcholinesterase is secreted from neuronal structures in the retina into the ocular fluid in an analogous manner to the secretion of acetylcholinesterase from brain neurones into cerebrospinal fluid.